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AlphaRet Overnight Cream

Photodamage, lines, wrinkles, uneven tone and texture.

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#1 dermatologist recommended non-prescription retinoid brand among medical aesthetic skincare brands ... Read full description

AlphaRet Overnight Cream

Photodamage, lines, wrinkles, uneven tone and texture.

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#1 dermatologist recommended non-prescription retinoid brand among medical aesthetic skincare brands*

AlphaRet Overnight Cream is an anti-aging face cream featuring patented AlphaRet Technology that combines a retinoid with an alpha hydroxy acid (AHA) to deliver visible skin rejuvenation with little-to-no irritation.

Why You'll Love It: Helps improve the appearance of fine lines and wrinkles, and helps refine the look of uneven skin tone and texture.

Be++er Retinoid. High Efficacy. High Tolerability.

All skinbetter science products are dermatologist tested, non-comedogenic, paraben free, fragrance free, dye free, and cruelty free.

*Among brands sold by physicians or medical practices, in addition to other outlets or retailers. Blinded nationwide survey of dermatologists 2025. Responding dermatologists may have sales relationships with one or more medical aesthetic brands.

AlphaRet is a clinically proven retinoid with 10 years of results. Designed for visible overnight skin rejuvenation with little-to-no irritation often experienced with retinols and other retinoid products, AlphaRet is formulated for all skin types.

  • Significantly reduces the appearance of wrinkles and fine lines in as little as four weeks, with little-to-no irritation.
  • Provides hydration and moisture to help counteract dryness associated with traditional retinoid-based products.
  • Combines two gold standard skin rejuvenation ingredients - a retinoid and an AHA (lactic acid) - in patented AlphaRet Technology for effective, tolerable overnight skin rejuvenation.
  • Features a blend of antioxidants to help neutralize free radicals.
AlphaRet is a patented technology that successfully combines a retinoid and an AHA for effective and tolerable skin rejuvenation. Explore more products featuring AlphaRet Technology.

16X AWARD-WINNER


  • 2016 ALLURE Best of Beauty Breakthrough
  • 2018 & 2019 lnStyle Best Beauty Buys - Best Wrinkle Cream
  • 2019 Cosmopolitan Skin Award - Best Retinol
  • 2020 & 2021 InStyle Best Beauty Buys - Best Night Cream
  • 2020 Shape Skin Award - Best Retinol
  • 2021 NewBeauty Award - Best Retinol Night Cream
  • 2021 Reader's Digest Editor's Choice Award - Best Moisturizer for Oily, Acne-Prone Skin
  • 2021 Harper's Bazaar UK Beauty Award - Best Retinol for Sensitive Skin
  • 2022 VOGUE - Best Wrinkle Cream
  • 2022 Shape Beauty Award - Best Night Cream
  • 2023 Good Housekeeping Best Beauty Award - Best Retinol
  • 2023 Byrdie Skin Award - Best Retinol
  • 2023 Shape Skin Award - Best Retinol
  • 2024 Prevention Healthy Skin Award - Best Anti-aging Cream for Normal Skin

  • Use as part of your evening skincare regime after cleansing.
  • Apply a thin layer of AlphaRet to a clean, dry face. Apply evenly all over the face, avoiding the eye area. Follow with other skinbetter science products in your evening regimen.
  • Protect with sunbetter sunscreen during the day for additional skincare benefits and daily sun protection.
  • Review recommended order of product application.

Sunburn Alert: This product contains an alpha hydroxy acid (AHA) that may increase your skin's sensitivity to the sun and particularly the possibility of sunburn. Use a sunscreen, wear protective clothing, and limit sun exposure while using this product and for a week afterwards. Caution: This product contains retinoid in a topical form. If you are pregnant, lactating or planning to become pregnant, consult a physician before use. If using more than one exfoliating product, irritation may occur.

KEY INGREDIENTS


  • AlphaRet: A unique combination of a retinoid and an AHA (lactic acid).
  • Glycolic Acid: Helps retexturize and enhances performance of AlphaRet.
  • Targeted Peptide Blend: Helps smooth the appearance of wrinkles, skin firmness and resiliency.
  • Ultra Hydrating Blend of Ceramides, Squalane, Niacinamide and Hyaluronic Acid: Helps to counteract dryness, providing hydration and moisture.
  • Allantoin Glycyrrhetinic Acid, Bisabolol, and Green Tea Extract: Ingredients with calming properties that also help reduce the appearance of redness.
  • Vitamins C & E and CoEnzyme Q10: Provide antioxidant protection.

Results

Results

 

Before/After Disclaimer


AlphaRet Overnight Cream was evaluated in a dermatologist-led clinical trial in 48 patients following evening application over 12 weeks.
*Twice-daily application of Even Tone Correcting Serum and evening application of AlphaRet Overnight Cream. Unretouched clinical photography on clean, product-free skin.

FAQ - M001
 
FAQ



Answers to your frequently asked questions.

Better Packaging

BETTER PACKAGING


skinbetter science packaging is thoughtfully designed to fully dispense from the inner bottle, giving you access to as much product as possible. This product features an airless container to help maintain the benefits of our proprietary formulations over the course of their shelf life. Our twist-up pumps control the amount of product dispensed and prevent leakage during travel and storage. And speaking of travel, this product is air travel friendly!

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