Lift and Defy Regimen

Name: Lift and Defy Regimen
SKU: M063
Price: 645 USD
Availability: InStock

The Lift and Defy Regimen is an innovative assembly of skinbetter science technologies designed to visibly refine texture, shield against environmental factors, and enhance plumpness, revealing a luminous and vibrant complexion.

Average rating includes incentivized reviews

The Lift and Defy regimen masterfully refines skin texture, enhances luminosity, and minimizes the a ... Read full description

Lift and Defy Regimen

The Lift and Defy Regimen is an innovative assembly of skinbetter science technologies designed to visibly refine texture, shield against environmental factors, and enhance plumpness, revealing a luminous and vibrant complexion.

Quantity

Alto Advanced Defense and Repair Serum

Improving skin brightness, repairing redness, overall tone and texture as a result of free radical damage from environmental and intrinsic stressors.
Quantity: 1

1.0 fl. oz. (30 ml)
InterFuse Treatment Cream EYE

Crow’s feet, wrinkles, puffiness and under-eye darkness.
Quantity: 1

0.5 fl. oz. (15 ml)
AlphaRet Overnight Cream

Photodamage, lines, wrinkles, uneven tone and texture.
Quantity: 1

1.0 fl. oz. (30 ml)
Ampra Volumizing Macro HA Serum

Lift skin with filler-inspired volume and contour. Ampra plumps, smooths, and lifts the appearance of skin, restoring fullness and redefining contours.
Quantity: 1

1.0 fl. oz. (30 ml)

or 4 installments of $161.25 by

Learn more

The Lift and Defy regimen masterfully refines skin texture, enhances luminosity, and minimizes the appearance of wrinkles, offering a truly transformative experience. Beyond visible rejuvenation, it provides comprehensive antioxidant defense and noticeably lifts and plumps to reveal a radiant, youthful-looking complexion.

InterFuse Treament Cream EYE 15 ml

A powerful, award-winning eye cream to recharge the eye area. Improves the appearance of crow's feet, wrinkles, puffiness and under-eye darkness.

Patented technology delivers ingredients more efficiently to maximize nourishing benefits.
A targeted peptide is designed to smooth the appearance of crow's feet almost immediately.
Improves the look of under-eye puffiness through a blend of caffeine and a highly specialized yeast derivative.
Diminishes dryness and locks in moisture with a synergistic blend of humectants.
Provides antioxidant and skin brightening benefits.

Alto Advanced Defense and Repair Serum 30 ml

Our gold-standard in internal and external antioxidant protection powered by two proprietary protectors in one clinically-proven innovation to address visual effects of aging.

Environmental Protection:

Proprietary complex of antioxidants that uniquely defends against a spectrum of environmental assaults.
Goes beyond Vitamins C and E to include 17 additional antioxidants.

Internal Protection:

Proprietary, highly advanced antioxidant protection that targets internal oxidative stress and supports the skin's renewal process.
Neutralizes intrinsic free radicals generated by the skin’s natural aging process.

Clinically demonstrated efficacy and tolerability:

Reduces UV-induced redness
Improves the appearance of skin dullness, texture and tone

*Clinically tested post non-ablative fractional laser
* Well tolerable for use post-procedure*
*Clinically tested post non-ablative fractional laser

Ampra Volumizing Macro HA Serum 30 ml

Visibly plumps, lifts, and redefines the look of facial contours for a smoother, firmer, and more youthful appearance. This innovative serum helps deliver HA and protect it from breakdown, sustaining its presence and activity. With continued use, the skin appears plumper, smoother, and more radiant, with contours visibly redefined.

Clinically Graded Attributes:

At Week 2¹

Improve the look of radiance by 27%
Improve the appearance of skin texture by 28%

At Week 12¹

Improve the appearance of plumpness by 32%
Improve the look of Sagging/Lift by 23%
Improve the appearance of Global lower face contours by 22%
Improves the appearance of skin texture by 40%
Improves the look of radiance by 39%
Improve the appearance of fine lines by 20%

¹ A 12-week, dermatologist-led clinical trial evaluated twice-daily use of Ampra Volumizing Macro HA Serum in women with visible volume loss and signs of aging (N=65).

AlphaRet Overnight Cream 30 ml

#1 dermatologist recommended non-prescription retinoid brand among medical aesthetic skincare brands.* AlphaRet is the latest innovation in retinoid renewal delivering remarkable results, with little-to-no irritation often experienced with retinols and other retinoid products.

*Significantly reduces the appearance of wrinkles in as little as four weeks, with little-to-no irritation.
*Provides moisture to help counteract dryness associated with traditional retinoid-based products.
*Combines two gold standard skin rejuvenation ingredients - a retinoid and an AHA (lactic acid) - joined together to create the revolutionary AlphaRet Technology that minimizes irritation, enhancing satisfaction and experience.
*A blend of antioxidants helps neutralize free radicals.
*AlphaRet is a patented technology that successfully combines a retinoid and an AHA for effective and tolerable skin rejuvenation.

*Among brands sold by physicians or medical practices, in addition to other outlets or retailers. Blinded nationwide survey of dermatologists 2025. Responding dermatologists may have sales relationships with one or more medical aesthetic brands.

InterFuse Treatment Cream EYE

3X AWARD-WINNER

2017 InStyle Best Beauty Buys - Best Anti-Aging Eye Cream
2021 Prevention Beauty Award - Outstanding Anti-Agers Category
2022 Reader's Digest Editor's Choice - Best Anti-Aging Eye Cream

Alto Advanced Defense and Repair Serum 30 ml

2022 Women's Health Skincare Award

AlphaRet Overnight Cream

14X AWARD-WINNER

2016 ALLURE Best of Beauty Breakthrough - Best Wrinkle Cream
2018 & 2019 lnStyle Best Beauty Buys - Best Wrinkle Cream
2019 Cosmopolitan Skin Award - Best Retinol
2020 & 2021 InStyle Best Beauty Buys - Best Night Cream
2020 Shape Skin Award - Best Retinol
2021 NewBeauty Award - Best Retinol Night Cream
2021 Reader's Digest Editor's Choice Award - Best Moisturizer for Oily, Acne-Prone Skin
2021 Harper's Bazaar UK Beauty Award - Best Retinol for Sensitive Skin
2022 VOGUE - Best Wrinkle Cream
2022 Shape Beauty Award - Best Night Cream
2023 Good Housekeeping Best Beauty Award - Best Retinol
2023 Shape Skin Award - Best Retinol

Morning

Step 1: After cleansing, apply a rice-grain amount of InterFuse Treatment Cream EYE around the delicate under-eye area.
Step 2: Apply a thin layer of Alto Advanced Defense and Repair Serum to face, neck, and décolleté.
Step 3: Dispense 1-2 pumps of Ampra Volumizing Macro HA Serum and apply. Allow to absorb.
Step 4: Apply a skinbetter science moisturizer of your choice as your final step: Trio Rebalancing Moisture Treatment or Trio Luxe Moisture Treatment. (not included in this set)

Protect with sunbetter sunscreen during the day for additional skincare benefits and daily sun protection.

Evening

Step 1: After cleansing, apply a rice-grain amount of InterFuse Treatment Cream EYE around the delicate under-eye area.
Step 2: Apply a thin layer of Alto Advanced Defense and Repair Serum to face, neck, and décolleté.
Step 3: Dispense 1-2 pumps of Ampra Volumizing Macro HA Serum and apply. Allow to absorb.
Step 4: Apply a thin layer of AlphaRet Overnight Cream to face at night, avoiding the eye area.
Step 5: Apply a skinbetter science moisturizer of your choice as your final step: Trio Rebalancing Moisture Treatment or Trio Luxe Moisture Treatment. (not included in this set)

Sunburn Alert: This regimen contains alpha hydroxy acid (AHA) that may increase your skin's sensitivity to the sun and particularly the possibility of sunburn. Use a sunscreen, wear protective clothing, and limit sun exposure while using this product and for a week afterwards. Caution: This product contains retinoid in a topical form. If you are pregnant, lactating or planning to become pregnant, consult a physician before use. If using more than one exfoliating product, irritation may occur.

InterFuse Treament Cream EYE

Blend of Messenger Peptides: Our approach to support collagen.
Neuro-Calming Peptide: Provides a smoothing and softening appearance of crepiness.
Kakadu Plum Extract: World’s highest source of Vitamin C, which brightens and improves the overall luminosity of the under-eye area.
Caffeine: Relieve the appearance of under-eye puffiness and congestion.
Niacinamide and Hyaluronic Acid: Deliver hydration to skin around the eyes.

Alto Advanced Defense and Repair Serum

Pyrroloquinoline Quinone Allyl Ester (Allyl PQQ): Patented, orange-red, super-potent antioxidant technology that effectively neutralizes free radicals produced by the body’s natural intrinsic processes.
Plankton Extract: Contains an enzyme that supports and helps rejuvenate the appearance of photodamage.
Micrococcus Lysate: Contains an enzyme that supports the skin’s natural recovery following sun exposure damage.
Proprietary Botanical Antioxidant Blend: Synergistic blend of antioxidant-rich plant extracts.
Vitamin C (Tetrahexyldecyl Ascorbate) & Vitamin E (Tocopheryl Acetate): Neutralize free radicals induced by sun exposure and other environmental aggressors.
Blend of Coffee, Saffron, Superoxide Dismutase and Ergothioneine: Enhances radiance.
Bisabolol (and) Zingiber Officinale (Ginger) Root Extract: Synergistic soothing complex. Helps visibly reduce redness and provides comfort to the skin.
Niacinamide: Form of Vitamin B3 helps improve moisture and the appearance of skin clarity.
Licorice Extract: Brightens skin’s appearance.
Palmitoyl Tripeptide-1: A peptide that helps support visibly firmer and smoother complexion.

Ampra Volumizing Macro HA Serum

HYAsync: Novel HA molecules where alpha-lipoic acid is structurally bonded to Hyaluronic Acid to help deliver, sustain, and protect HA molecules.
Hydrolyzed Sodium Hyaluronate: Known to provide antioxidant support and moisture.
Hydrolyzed Yeast Extract (and) Polyglucuronic Acid: Biofermented active ingredient designed to enhance HA, delivering hydration for supple skin, reduction in wrinkle depth and density, improvement in skin smoothness and roughness, and a visible lifting effect.
Hydrolyzed Eragrostis Tef Seed Extract: Superfood extract that helps support collagen and elasticity for younger-looking skin.
Palmitoyl Tripeptide-38: Peptide focused on supporting the ECM for visibly smoother and plumper skin.
Jojoba Esters: Supports the skin barrier function and provides hydration.
Niacinamide: Form of Vitamin B2, helps strengthen the skin’s moisture barrier.
Squalane: A lipid that forms a protective layer on skin to help lock in moisture.

AlphaRet Overnight Cream

Glycolic Acid: Helps retexturize and enhances performance of AlphaRet.
Targeted Peptide Blend: Helps smooth the appearance of wrinkles, skin firmness and resiliency.
Ultra Hydrating Blend of Ceramides, Squalane, Niacinamide and Hyaluronic Acid: Helps to counteract dryness, providing hydration and moisture.
Allantoin Glycyrrhetinic Acid, Bisabolol, and Green Tea Extract: Ingredients with calming properties that also help reduce the appearance of redness.
Vitamins C & E and CoEnzyme Q10: Provide antioxidant protection.

FULL INGREDIENT LIST

KEY INGREDIENTS

InterFuse Treament Cream EYE

Aqua/Water, Caprylyl Methicone, Glycerin, Jojoba Esters, Niacinamide, PEG-16 Macadamia Glycerides, Cetearyl Alcohol, Glyceryl Stearate, Ceteareth-20, PEG-100 Stearate, Caprylic/Capric Triglyceride, Alcohol Denat., Palmitoyl Tripeptide-38, Caffeine, s-Mu-conotoxin CnIIIC Acetate, Copper Lysinate/Prolinate, Hydrolyzed Lupine Protein, Terminalia Ferdinandiana Fruit Extract, Methylglucoside Phosphate, Sodium Hyaluronate, Saccharomyces Cerevisiae Extract, Arginine, Glycine, Hydroxypropyl Cyclodextrin, Carbomer, Hexylene Glycol, Citric Acid, Sodium Hydroxide, Ethylhexylglycerin, Caprylyl Glycol, Phenoxyethanol.

Alto Advanced Defense and Repair Serum

2076511 5 – Aqua/Water/Eau, Butylene Glycol, Propanediol, Ethylhexyl Olivate, Cetearyl Alcohol, Chlorogenic Acids, Niacinamide, Lauryl Lactate, Dimethyl Isosorbide, Pyrroloquinoline Quinone Allyl Ester, Hydrolyzed Sodium Hyaluronate, Glycyrrhiza Glabra Root Extract/Licorice Root Extract, Tetrahexyldecyl Ascorbate, Ergothioneine, Taraxacum Officinale Rhizome/Root Extract - Dandelion Rhizome/Root Extract, Arabidopsis Thaliana Extract, Carnosine, Camellia Sinensis Leaf Extract, Vitis Vinifera Seed Extract/Grape Seed Extract, Theobroma Cacao Seed Extract/Cocoa Seed Extract, Curcuma Longa Root Extract/Turmeric Root Extract, Olea Europaea Fruit Extract/Olive Fruit Extract, Euterpe Oleracea Fruit Extract, Palmitoyl Tripeptide-1, Buddleja Officinalis Flower Extract, Coffea Arabica Seed Extract/Coffee Seed Extract, Crocus Sativus Flower Extract, Superoxide Dismutase, Ubiquinone, Plankton Extract, Micrococcus Lysate, Arginine, Zingiber Officinale Root Extract/Ginger Root Extract, Ceramide NP, Ceramide AP, Ceramide EOP, Linoleic Acid, Linolenic Acid, Ascorbic Acid, Bisabolol, Tocopherol, Tocopheryl Acetate, Cholesterol, Phytosphingosine, Jojoba Esters, Sodium PCA, Methyl Gluceth-20, Glycerin, Helianthus Annuus Seed Cera/Sunflower Seed Wax, Acacia Decurrens Flower Cera/Acacia Decurrens Flower Wax, Lecithin, Sodium Lauroyl Lactylate, Dicetyl Phosphate, Propanediol Dicaprylate/Caprate, Polyglycerin-3, Ceteth-20 Phosphate, Diisostearyl Malate, Xanthan Gum, Steareth-2, Acacia Senegal Gum, Pentaerythrityl Tetra-di-t-butyl Hydroxyhydrocinnamate, Carbomer, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Maltodextrin, Ricinoleth-40, Sodium Hydroxide, Citric Acid, Sodium Phytate, Ethylhexylglycerin, Phenoxyethanol, Ethylhexyl Palmitate, Alcohol, Lactic Acid, Pentylene Glycol, Sorbitan Isostearate, Tribehenin, N70044495/2.

Ampra Volumizing Macro HA Serum

2076538 25 - Aqua/Water/Eau, Glycerin, Isocetyl Stearoyl Stearate, Niacinamide, Pentylene Glycol, Jojoba Esters, Hydrolyzed Yeast Extract, Squalane, Glycol Palmitate, Cetyl Alcohol, Lecithin, Sodium Methyl, Stearoyl Taurate, Sodium Thioctoyl/Formoyl Hyaluronate, Palmitoyl Tripeptide-38, Hydrolyzed Eragrostis Tef Seed Extract, Hydrolyzed Sodium Hyaluronate, Hydroxypropyl Cyclodextrin, Tetrasodium Glutamate Diacetate, Citric Acid, Xanthan Gum, Polyglucuronic Acid, Cetyl Hydroxyethylcellulose, Tocopherol, Potassium Sorbate, Sodium Benzoate, Phenoxyethanol, N70091177/1.

AlphaRet Overnight Cream

Aqua/Water, Sodium Glycolate, Glycolic Acid, Cetearyl Olivate, Pentylene Glycol, Cyclopentasiloxane, Isohexadecane, Sorbitan Olivate, Tetrahexyldecyl Ascorbate, Glycerin, Ceresin, Glycol Palmitate, Butylene Glycol, Niacinamide, Squalane, Methyl Gluceth-20, Ethyl Lactyl Retinoate, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Ceramide NP, Hyaluronic Acid, Ubiquinone, Tocopherol, Bisabolol, Tocopheryl Acetate, Superoxide Dismutase, Butyrospermum Parkii (Shea) Butter, Allantoin Glycyrrhetinic Acid, Sodium PCA, Panthenol, Camellia Sinensis Leaf Extract, Portulaca Oleracea Extract, Linoleic Acid, Cholesterol, Linolenic Acid, Magnesium Aluminum Silicate, Dimethyl Isosorbide, Dimethicone, Glyceryl Stearate, PEG-100 Stearate, Steareth-2, Hydroxyethylcellulose, Acacia Senegal Gum, Xanthan Gum, Hydrated Silica, Carbomer, Polysorbate 20, Disodium EDTA, Ethylhexylglycerin, Phenoxyethanol, Titanium Dioxide (CI 77891)

BETTER PACKAGING

skinbetter science packaging is thoughtfully designed to fully dispense from the inner bottle, giving you access to as much product as possible. This product features an airless container to help maintain the benefits of our proprietary formulations over the course of their shelf life. Our twist-up pumps control the amount of product dispensed and prevent leakage during travel and storage. And speaking of travel, this product is air travel friendly!